8B7B

Tubulin - maytansinoid - 6 complex

8B7B の概要

• エントリーDOI: 10.2210/pdb8b7b/pdb
• 分子名称: Tubulin alpha-1B chain, GLYCEROL, (~{Z})-11-[[(1~{R},2~{R},3~{S},5~{S},6~{S},16~{E},18~{E},20~{R},21~{S})-11-chloranyl-12,20-dimethoxy-2,5,9,16-tetramethyl-21-oxidanyl-8,23-bis(oxidanylidene)-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1^{10,14}.0^{3,5}]hexacosa-10(26),11,13,16,18-pentaen-6-yl]oxy]-11-oxidanylidene-undec-2-enoic acid, ... (13 entities in total)
• 機能のキーワード: cell cycle, tubulin fold, cytoskeleton, microtubule
• 由来する生物種: Rattus norvegicus (Norway rat); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 265439.84

構造登録者

Boiarska, Z.,Perez-Pena, H.,Abel, A.-C.,Marzullo, P.,Alvarez-Bernad, B.,Bonato, F.,Santini, B.,Horvath, D.,Lucena-Agell, D.,Vasile, F.,Sironi, M.,Diaz, J.F.,Steinmetz, M.O.,Prota, A.E.,Pieraccini, S.,Passarella, D. (登録日: 2022-09-29, 公開日: 2023-08-23)

• 主引用文献: Boiarska, Z.,Perez-Pena, H.,Abel, A.C.,Marzullo, P.,Alvarez-Bernad, B.,Bonato, F.,Santini, B.,Horvath, D.,Lucena-Agell, D.,Vasile, F.,Sironi, M.,Diaz, J.F.,Prota, A.E.,Pieraccini, S.,Passarella, D.; Maytansinol Functionalization: Towards Useful Probes for Studying Microtubule Dynamics.; Chemistry, 29:e202203431-e202203431, 2023; PubMed: 36468686; DOI: 10.1002/chem.202203431

実験手法

X-RAY DIFFRACTION (2.25 Å)