8B4W

X-ray structure of furin (PCSK3) in complex with 1H-isoindol-3-amine

Summary for 8B4W

• Entry DOI: 10.2210/pdb8b4w/pdb
• Descriptor: Furin, 1H-isoindol-3-amine, CALCIUM ION, ... (8 entities in total)
• Functional Keywords: furin, proprotein convertase subtilisin/kexin type 3, pcsk3, sars-cov-2, inhibitor, protease, complex, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 53212.05

Authors

Dahms, S.O.,Brandstetter, H. (deposition date: 2022-09-21, release date: 2023-10-04, Last modification date: 2024-05-15)

• Primary citation: Lange, R.W.,Bloch, K.,Heindl, M.R.,Wollenhaupt, J.,Weiss, M.S.,Brandstetter, H.,Klebe, G.,Falcone, F.H.,Bottcher-Friebertshauser, E.,Dahms, S.O.,Steinmetzer, T.; Fragment-Based Design, Synthesis, and Characterization of Aminoisoindole-Derived Furin Inhibitors.; Chemmedchem, 19:e202400057-e202400057, 2024; PubMed: 38385828; DOI: 10.1002/cmdc.202400057

Experimental method

X-RAY DIFFRACTION (1.6 Å)