8B3Z

SigE N-terminal Domain

Summary for 8B3Z

• Entry DOI: 10.2210/pdb8b3z/pdb
• Descriptor: RNA polymerase sigma factor (2 entities in total)
• Functional Keywords: sigma factor, dna binding protein
• Biological source: Bacillus subtilis
• Total number of polymer chains: 6
• Total formula weight: 56406.13

Authors

Evans, N.J.,Isaacson, R.L.,Collins, K.M.,Camp, A.H. (deposition date: 2022-09-18, release date: 2023-08-23, Last modification date: 2023-08-30)

Primary citation

Collins, K.M.,Evans, N.J.,Torpey, J.H.,Harris, J.M.,Haynes, B.A.,Camp, A.H.,Isaacson, R.L.
Structural Analysis of Bacillus subtilis Sigma Factors.
Microorganisms, 11:-, 2023

PubMed Abstract: Bacteria use an array of sigma factors to regulate gene expression during different stages of their life cycles. Full-length, atomic-level structures of sigma factors have been challenging to obtain experimentally as a result of their many regions of intrinsic disorder. AlphaFold has now supplied plausible full-length models for most sigma factors. Here we discuss the current understanding of the structures and functions of sigma factors in the model organism, , and present an X-ray crystal structure of a region of SigE, a sigma factor that plays a critical role in the developmental process of spore formation.

PubMed: 37110501
DOI: 10.3390/microorganisms11041077

Experimental method

X-RAY DIFFRACTION (2.38 Å)