8AXP

Neisseria gonorrhoeae peptidyl-tRNA hydrolase complexed with an XChem hit.

8AXP の概要

• エントリーDOI: 10.2210/pdb8axp/pdb
• 分子名称: Peptidyl-tRNA hydrolase, N-[4-(2-amino-1,3-thiazol-4-yl)phenyl]acetamide, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: inhibitor, complex, hydrolase
• 由来する生物種: Neisseria gonorrhoeae
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 44098.30

構造登録者

Roe, S.M.,Fearon, D. (登録日: 2022-08-31, 公開日: 2022-11-09, 最終更新日: 2024-01-31)

主引用文献

Hassell-Hart, S.,Speranzini, E.,Srikwanjai, S.,Hossack, E.,Roe, S.M.,Fearon, D.,Akinbosede, D.,Hare, S.,Spencer, J.
Synthesis of a Thiazole Library via an Iridium-Catalyzed Sulfur Ylide Insertion Reaction.
Org.Lett., 24:7924-7927, 2022

PubMed Abstract: A library of thiazoles and selenothiazoles were synthesized via Ir-catalyzed ylide insertion chemistry. This process is a functional group, particularly heterocycle-substituent tolerant. This was applied to the synthesis of fanetizole, an anti-inflammatory drug, and a thiazole-containing drug fragment that binds to the peptidyl-tRNA hydrolase (Pth) in Neisseria gonorrheae bacteria.

PubMed: 36265082
DOI: 10.1021/acs.orglett.2c02996

実験手法

X-RAY DIFFRACTION (1.83 Å)