8AX3

Structure of recombinant human beta-glucocerebrosidase in complex with L-carbaxylosyl fluoride

8AX3 の概要

• エントリーDOI: 10.2210/pdb8ax3/pdb
• 関連するPDBエントリー: 8AWK 8AWR
• 分子名称: Lysosomal acid glucosylceramidase, CALCIUM ION, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• 機能のキーワード: beta-glucocerebrosidase, glycoside hydrolase, inhibitor, carbasugar, pharmacological chaperone, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 117599.60

構造登録者

Rowland, R.J.,Davies, G.J. (登録日: 2022-08-30, 公開日: 2024-03-13)

• 主引用文献: Bhosale, S.,Kandalkar, S.,Gilormini, P.A.,Akintola, O.,Rowland, R.J.,Adabala, P.J.P.,King, D.,Deen, M.C.,Xi, K.,Davies, G.J.,Vocadlo, D.J.,Bennet, A.J.; Single turnover covalent inhibitors for functional chaperoning of lysosomal glycoside hydrolases; To be published,

実験手法

X-RAY DIFFRACTION (1.59 Å)