8AW1

c-MET Y1235D mutant in complex with Tepotinib

8AW1 の概要

• エントリーDOI: 10.2210/pdb8aw1/pdb
• 分子名称: Hepatocyte growth factor receptor, 3-[1-(3-{5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl}benzyl)-6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile (3 entities in total)
• 機能のキーワード: protein kinase, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68777.72

構造登録者

Graedler, U.,Lammens, A. (登録日: 2022-08-29, 公開日: 2023-09-06, 最終更新日: 2024-03-20)

• 主引用文献: Gradler, U.,Schwarz, D.,Wegener, A.,Eichhorn, T.,Bandeiras, T.M.,Freitas, M.C.,Lammens, A.,Ganichkin, O.,Augustin, M.,Minguzzi, S.,Becker, F.,Bomke, J.; Biophysical and structural characterization of the impacts of MET phosphorylation on tepotinib binding.; J.Biol.Chem., 299:105328-105328, 2023; PubMed: 37806493; DOI: 10.1016/j.jbc.2023.105328

実験手法

X-RAY DIFFRACTION (2.14 Å)