8AUZ
Crystal structure of GSK3 beta (GSK3b) in complex with FL291.
Summary for 8AUZ
Entry DOI | 10.2210/pdb8auz/pdb |
Descriptor | Glycogen synthase kinase-3 beta, SULFATE ION, 8-morpholin-4-yl-2-pyridin-3-yl-[1,3]oxazolo[5,4-f]quinoxaline, ... (4 entities in total) |
Functional Keywords | kinase, gsk3b, inhibitor, structural genomics, structural genomics consortium, sgc, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 84238.31 |
Authors | Chaikuad, A.,Mongin, F.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2022-08-26, release date: 2023-04-19, Last modification date: 2024-02-07) |
Primary citation | Hasyeoui, M.,Lassagne, F.,Erb, W.,Nael, M.,Elokely, K.M.,Chaikuad, A.,Knapp, S.,Jorda, A.,Valles, S.L.,Quissac, E.,Verreault, M.,Robert, T.,Bach, S.,Samarat, A.,Mongin, F. Oxazolo[5,4-f]quinoxaline-type selective inhibitors of glycogen synthase kinase-3 alpha (GSK-3 alpha ): Development and impact on temozolomide treatment of glioblastoma cells. Bioorg.Chem., 134:106456-106456, 2023 Cited by PubMed: 36913879DOI: 10.1016/j.bioorg.2023.106456 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.66 Å) |
Structure validation
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