8AUZ

Crystal structure of GSK3 beta (GSK3b) in complex with FL291.

Summary for 8AUZ

• Entry DOI: 10.2210/pdb8auz/pdb
• Descriptor: Glycogen synthase kinase-3 beta, SULFATE ION, 8-morpholin-4-yl-2-pyridin-3-yl-[1,3]oxazolo[5,4-f]quinoxaline, ... (4 entities in total)
• Functional Keywords: kinase, gsk3b, inhibitor, structural genomics, structural genomics consortium, sgc, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 84238.31

Authors

Chaikuad, A.,Mongin, F.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2022-08-26, release date: 2023-04-19, Last modification date: 2024-02-07)

• Primary citation: Hasyeoui, M.,Lassagne, F.,Erb, W.,Nael, M.,Elokely, K.M.,Chaikuad, A.,Knapp, S.,Jorda, A.,Valles, S.L.,Quissac, E.,Verreault, M.,Robert, T.,Bach, S.,Samarat, A.,Mongin, F.; Oxazolo[5,4-f]quinoxaline-type selective inhibitors of glycogen synthase kinase-3 alpha (GSK-3 alpha ): Development and impact on temozolomide treatment of glioblastoma cells.; Bioorg.Chem., 134:106456-106456, 2023; PubMed: 36913879; DOI: 10.1016/j.bioorg.2023.106456

Experimental method

X-RAY DIFFRACTION (2.66 Å)