8AUZ

Crystal structure of GSK3 beta (GSK3b) in complex with FL291.

8AUZ の概要

• エントリーDOI: 10.2210/pdb8auz/pdb
• 分子名称: Glycogen synthase kinase-3 beta, SULFATE ION, 8-morpholin-4-yl-2-pyridin-3-yl-[1,3]oxazolo[5,4-f]quinoxaline, ... (4 entities in total)
• 機能のキーワード: kinase, gsk3b, inhibitor, structural genomics, structural genomics consortium, sgc, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 84238.31

構造登録者

Chaikuad, A.,Mongin, F.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2022-08-26, 公開日: 2023-04-19, 最終更新日: 2024-02-07)

• 主引用文献: Hasyeoui, M.,Lassagne, F.,Erb, W.,Nael, M.,Elokely, K.M.,Chaikuad, A.,Knapp, S.,Jorda, A.,Valles, S.L.,Quissac, E.,Verreault, M.,Robert, T.,Bach, S.,Samarat, A.,Mongin, F.; Oxazolo[5,4-f]quinoxaline-type selective inhibitors of glycogen synthase kinase-3 alpha (GSK-3 alpha ): Development and impact on temozolomide treatment of glioblastoma cells.; Bioorg.Chem., 134:106456-106456, 2023; PubMed: 36913879; DOI: 10.1016/j.bioorg.2023.106456

実験手法

X-RAY DIFFRACTION (2.66 Å)