8ATS

Small molecular stabilizer for C-RAF (pS259) and 14-3-3 (1075306)

8ATS の概要

• エントリーDOI: 10.2210/pdb8ats/pdb
• 分子名称: 14-3-3 protein sigma, RAF proto-oncogene serine/threonine-protein kinase, CHLORIDE ION, ... (6 entities in total)
• 機能のキーワード: 14-3-3, eralpha, stabilization, covalent, structural protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28133.66

構造登録者

Visser, E.J.,Overmans, M.J.A.M.,Vandenboorn, E.M.F.,Ottmann, C. (登録日: 2022-08-24, 公開日: 2023-09-20, 最終更新日: 2023-10-04)

• 主引用文献: Konstantinidou, M.,Visser, E.J.,Vandenboorn, E.,Chen, S.,Jaishankar, P.,Overmans, M.,Dutta, S.,Neitz, R.J.,Renslo, A.R.,Ottmann, C.,Brunsveld, L.,Arkin, M.R.; Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3 sigma /ER alpha Protein-Protein Interaction from Nonselective Fragments.; J.Am.Chem.Soc., 145:20328-20343, 2023; PubMed: 37676236; DOI: 10.1021/jacs.3c05161

実験手法

X-RAY DIFFRACTION (1.4 Å)