8ATO
Structure of the giant inhibitor of apoptosis, BIRC6 bound to the regulator SMAC
This is a non-PDB format compatible entry.
Summary for 8ATO
Entry DOI | 10.2210/pdb8ato/pdb |
Related | 8ATM |
EMDB information | 15654 |
Descriptor | Baculoviral IAP repeat-containing protein 6, Diablo IAP-binding mitochondrial protein (2 entities in total) |
Functional Keywords | e2/e3 ubiquitin ligase, apoptosis |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 1103528.20 |
Authors | Dietz, L.,Elliott, P.R. (deposition date: 2022-08-23, release date: 2023-03-08, Last modification date: 2024-07-24) |
Primary citation | Dietz, L.,Ellison, C.J.,Riechmann, C.,Cassidy, C.K.,Felfoldi, F.D.,Pinto-Fernandez, A.,Kessler, B.M.,Elliott, P.R. Structural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase BIRC6. Science, 379:1112-1117, 2023 Cited by PubMed: 36758106DOI: 10.1126/science.ade8840 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3 Å) |
Structure validation
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