8ASF

Crystal structure of Thrombin in complex with macrocycle T1

Summary for 8ASF

• Entry DOI: 10.2210/pdb8asf/pdb
• Descriptor: Thrombin light chain, Thrombin heavy chain, 5-chloranyl-~{N}-[[(9~{S},15~{R})-8,14,17-tris(oxidanylidene)-3,20-dithia-7,13,16-triazatetracyclo[20.2.2.1^{5,7}.1^{9,13}]octacosa-1(25),22(26),23-trien-15-yl]methyl]thiophene-2-carboxamide, ... (4 entities in total)
• Functional Keywords: serine endopeptidases, alpha-thrombin, activated factor iia, fibrinogenase, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 69024.03

Authors

Chinellato, M.,Angelini, A.,Nielsen, A.,Heinis, C.,Cendron, L. (deposition date: 2022-08-19, release date: 2024-03-06)

• Primary citation: Nielsen, A.,Chinellato, M.,Cendron, L.,Angelini, A.,Heinis, C.; Crystal structure of Thrombin in complex with optimized macrocycles T1 and T3; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.58 Å)