8ASF

Crystal structure of Thrombin in complex with macrocycle T1

8ASF の概要

• エントリーDOI: 10.2210/pdb8asf/pdb
• 分子名称: Thrombin light chain, Thrombin heavy chain, 5-chloranyl-~{N}-[[(9~{S},15~{R})-8,14,17-tris(oxidanylidene)-3,20-dithia-7,13,16-triazatetracyclo[20.2.2.1^{5,7}.1^{9,13}]octacosa-1(25),22(26),23-trien-15-yl]methyl]thiophene-2-carboxamide, ... (4 entities in total)
• 機能のキーワード: serine endopeptidases, alpha-thrombin, activated factor iia, fibrinogenase, hydrolase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 69024.03

構造登録者

Chinellato, M.,Angelini, A.,Nielsen, A.,Heinis, C.,Cendron, L. (登録日: 2022-08-19, 公開日: 2024-03-06)

• 主引用文献: Nielsen, A.,Chinellato, M.,Cendron, L.,Angelini, A.,Heinis, C.; Crystal structure of Thrombin in complex with optimized macrocycles T1 and T3; To Be Published,

実験手法

X-RAY DIFFRACTION (2.58 Å)