8ASB

Structure of the SFTSV L protein stalled at early elongation with the endonuclease domain in a raised conformation [EARLY-ELONGATION-ENDO]

Summary for 8ASB

• Entry DOI: 10.2210/pdb8asb/pdb
• Related: 8AS6 8AS7 8ASB 8ASD
• EMDB information: 15610
• Descriptor: RNA-dependent RNA-polymerase L protein, RNA (5'-R(*AP*CP*AP*CP*AP*GP*AP*GP*AP*CP*GP*CP*CP*CP*AP*GP*A)-3'), RNA (5'-R(P*UP*CP*UP*GP*GP*GP*CP*GP*GP*UP*CP*UP*UP*UP*GP*UP*GP*U)-3'), ... (6 entities in total)
• Functional Keywords: sftsv rna-dependent rna polymerase, viral rna, viral protein
• Biological source: SFTS virus AH12; More
• Total number of polymer chains: 4
• Total formula weight: 259252.86

Authors

Williams, H.M.,Thorkelsson, S.R.,Vogel, D.,Milewski, M.,Busch, C.,Cusack, S.,Grunewald, K.,Quemin, E.R.J.,Rosenthal, M. (deposition date: 2022-08-18, release date: 2023-01-18, Last modification date: 2023-03-01)

• Primary citation: Williams, H.M.,Thorkelsson, S.R.,Vogel, D.,Milewski, M.,Busch, C.,Cusack, S.,Grunewald, K.,Quemin, E.R.J.,Rosenthal, M.; Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein.; Nucleic Acids Res., 51:1424-1442, 2023; PubMed: 36651274; DOI: 10.1093/nar/gkac1249

Experimental method

ELECTRON MICROSCOPY (3.6 Å)