8AQB
Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus in Complex with Inhibitor MI-2257
Summary for 8AQB
| Entry DOI | 10.2210/pdb8aqb/pdb |
| Descriptor | Serine protease subunit NS2B, Serine protease NS3, (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside, ... (5 entities in total) |
| Functional Keywords | flavivirin, serine protease, viral protein, ns2b-ns3, zika virus |
| Biological source | Zika virus More |
| Total number of polymer chains | 3 |
| Total formula weight | 25669.86 |
| Authors | Huber, S.,Steinmetzer, T. (deposition date: 2022-08-11, release date: 2022-12-21, Last modification date: 2024-06-12) |
| Primary citation | Huber, S.,Braun, N.J.,Schmacke, L.C.,Murra, R.,Bender, D.,Hildt, E.,Heine, A.,Steinmetzer, T. Synthesis and structural characterization of new macrocyclic inhibitors of the Zika virus NS2B-NS3 protease. Arch Pharm, :e2400250-e2400250, 2024 Cited by PubMed: 38809037DOI: 10.1002/ardp.202400250 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.28 Å) |
Structure validation
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