8AOQ

Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with compound 20a

Summary for 8AOQ

Entry DOI	10.2210/pdb8aoq/pdb
Descriptor	Cereblon isoform 4, ZINC ION, (3~{S})-3-(phenylsulfonylmethyl)piperidine-2,6-dione, ... (4 entities in total)
Functional Keywords	proteolysis targeting chimera, protac, protein degradation, signaling protein
Biological source	Magnetospirillum gryphiswaldense
Total number of polymer chains	3
Total formula weight	41628.33
Authors	Maiwald, S.,Heim, C.,Hartmann, M.D. (deposition date: 2022-08-08, release date: 2023-01-11, Last modification date: 2024-02-07)
Primary citation	Krasavin, M.,Adamchik, M.,Bubyrev, A.,Heim, C.,Maiwald, S.,Zhukovsky, D.,Zhmurov, P.,Bunev, A.,Hartmann, M.D. Synthesis of novel glutarimide ligands for the E3 ligase substrate receptor Cereblon (CRBN): Investigation of their binding mode and antiproliferative effects against myeloma cell lines. Eur.J.Med.Chem., 246:114990-114990, 2023 Cited by PubMed: 36476642 DOI: 10.1016/j.ejmech.2022.114990 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.088 Å)

Structure validation