8AOQ
Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with compound 20a
Summary for 8AOQ
Entry DOI | 10.2210/pdb8aoq/pdb |
Descriptor | Cereblon isoform 4, ZINC ION, (3~{S})-3-(phenylsulfonylmethyl)piperidine-2,6-dione, ... (4 entities in total) |
Functional Keywords | proteolysis targeting chimera, protac, protein degradation, signaling protein |
Biological source | Magnetospirillum gryphiswaldense |
Total number of polymer chains | 3 |
Total formula weight | 41628.33 |
Authors | Maiwald, S.,Heim, C.,Hartmann, M.D. (deposition date: 2022-08-08, release date: 2023-01-11, Last modification date: 2024-02-07) |
Primary citation | Krasavin, M.,Adamchik, M.,Bubyrev, A.,Heim, C.,Maiwald, S.,Zhukovsky, D.,Zhmurov, P.,Bunev, A.,Hartmann, M.D. Synthesis of novel glutarimide ligands for the E3 ligase substrate receptor Cereblon (CRBN): Investigation of their binding mode and antiproliferative effects against myeloma cell lines. Eur.J.Med.Chem., 246:114990-114990, 2023 Cited by PubMed: 36476642DOI: 10.1016/j.ejmech.2022.114990 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.088 Å) |
Structure validation
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