8AM6
Cyclohexanone dehydrogenase (CDH) from Alicycliphilus denitrificans K601 complexed with dehydrogenated substrate cyclohex-2-en-1-one - inactive mutant (Y195F)
This is a non-PDB format compatible entry.
Summary for 8AM6
Entry DOI | 10.2210/pdb8am6/pdb |
Related | 8AM3 |
Descriptor | Fumarate reductase/succinate dehydrogenase flavoprotein domain protein, FLAVIN-ADENINE DINUCLEOTIDE, cyclohex-2-en-1-one, ... (6 entities in total) |
Functional Keywords | fad, cyclic ketone, enzyme engineering, rational design, flavoprotein |
Biological source | Alicycliphilus denitrificans K601 |
Total number of polymer chains | 2 |
Total formula weight | 134798.40 |
Authors | Prior, S.H.,Taylor, E.J. (deposition date: 2022-08-02, release date: 2024-02-14, Last modification date: 2024-04-10) |
Primary citation | Singh, W.,Brown, N.L.,McCue, H.V.,Marriott, S.R.,Wilson, R.C.,Perry, J.,Turkenburg, J.P.,Dubey, K.D.,Prior, S.H.,Carnell, A.J.,Taylor, E.J.,Black, G.W. Rational design of a cyclohexanone dehydrogenase for enhanced alpha , beta-desaturation and substrate specificity. Chem Sci, 15:4969-4980, 2024 Cited by PubMed: 38550701DOI: 10.1039/d3sc04009g PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.33 Å) |
Structure validation
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