8AM2

Human butyrylcholinesterase in complex with 2,2'-(((1E,1'E)-(2-phenylpyrimidine-4,6-diyl)bis(methaneylylidene))bis(hydrazin-1-yl-2-ylidene))bis(N,N,N-trimethyl-2-oxoethan-1-aminium)

8AM2 の概要

• エントリーDOI: 10.2210/pdb8am2/pdb
• 分子名称: Cholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ~{N}-[(~{E})-[2-phenyl-6-[[2-[2-(trimethyl-$l^{4}-azanyl)ethanoyl]hydrazinyl]methyl]pyrimidin-4-yl]methylideneamino]-2-(trimethyl-$l^{4}-azanyl)ethanamide, ... (8 entities in total)
• 機能のキーワード: inhibitor, complex, butyrylcholinesterase, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 62764.69

構造登録者

Nachon, F.,Brazzolotto, X.,Dias, J. (登録日: 2022-08-02, 公開日: 2023-06-14, 最終更新日: 2024-02-07)

• 主引用文献: Nachon, F.,Brazzolotto, X.,Dias, J.,Courageux, C.,Drozdz, W.,Cao, X.Y.,Stefankiewicz, A.R.,Lehn, J.M.; Grid-Type Quaternary Metallosupramolecular Compounds Inhibit Human Cholinesterases through Dynamic Multivalent Interactions.; Chembiochem, 23:e202200456-e202200456, 2022; PubMed: 36193860; DOI: 10.1002/cbic.202200456

実験手法

X-RAY DIFFRACTION (2.5 Å)