8AKK

Acyl-enzyme complex of imipenem bound to deacylation mutant KPC-2 (E166Q)

8AKK の概要

• エントリーDOI: 10.2210/pdb8akk/pdb
• 分子名称: Carbapenem-hydrolyzing beta-lactamase KPC, Imipenem, (2R,4S)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4-[(2-{[(Z)-iminomethyl]amino}ethyl)sulfanyl]-3,4-dihydro-2H-pyrrole-5-ca rboxylic acid, ... (6 entities in total)
• 機能のキーワード: acyl-enzyme complex, antibiotic resistance, beta-lactamase, antibiotic, ligand, antimicrobial protein
• 由来する生物種: Klebsiella pneumoniae
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31896.75

構造登録者

Tooke, C.L.,Hinchliffe, P.,Spencer, J. (登録日: 2022-07-29, 公開日: 2023-03-08, 最終更新日: 2024-02-07)

• 主引用文献: Tooke, C.L.,Hinchliffe, P.,Beer, M.,Zinovjev, K.,Colenso, C.K.,Schofield, C.J.,Mulholland, A.J.,Spencer, J.; Tautomer-Specific Deacylation and Omega-Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC-2 beta-Lactamase.; J.Am.Chem.Soc., 145:7166-7180, 2023; PubMed: 36972204; DOI: 10.1021/jacs.2c12123

実験手法

X-RAY DIFFRACTION (1.36 Å)