8AKB
Human Sirt6 in complex with ADP-ribose and fragment 4-nitrocatechol
Summary for 8AKB
Entry DOI | 10.2210/pdb8akb/pdb |
Descriptor | NAD-dependent protein deacetylase sirtuin-6, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, ZINC ION, ... (8 entities in total) |
Functional Keywords | deacylase, fragment, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 69437.36 |
Authors | |
Primary citation | You, W.,Steegborn, C. Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.13 Å) |
Structure validation
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