8AI6

Crystal structure of radical SAM epimerase EpeE D210A mutant from Bacillus subtilis with [4Fe-4S] clusters, S-adenosyl-L-homocysteine and persulfurated cysteine bound

8AI6 の概要

• エントリーDOI: 10.2210/pdb8ai6/pdb
• 分子名称: Putative peptide biosynthesis protein YydG, IRON/SULFUR CLUSTER, S-ADENOSYL-L-HOMOCYSTEINE, ... (6 entities in total)
• 機能のキーワード: radical sam, metalloenzyme, iron-sulfur, ripp, metal binding protein
• 由来する生物種: Bacillus subtilis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 83491.97

構造登録者

Polsinelli, I.,Legrand, P.,Fyfe, C.D.,Benjdia, A.,Berteau, O. (登録日: 2022-07-25, 公開日: 2024-01-10, 最終更新日: 2024-03-13)

• 主引用文献: Kubiak, X.,Polsinelli, I.,Chavas, L.M.G.,Fyfe, C.D.,Guillot, A.,Fradale, L.,Brewee, C.,Grimaldi, S.,Gerbaud, G.,Thureau, A.,Legrand, P.,Berteau, O.,Benjdia, A.; Structural and mechanistic basis for RiPP epimerization by a radical SAM enzyme.; Nat.Chem.Biol., 20:382-391, 2024; PubMed: 38158457; DOI: 10.1038/s41589-023-01493-1

実験手法

X-RAY DIFFRACTION (1.95 Å)