8AHH
PAC FragmentDEL: Photoactivated covalent capture of DNA encoded fragments for hit discovery
Summary for 8AHH
Entry DOI | 10.2210/pdb8ahh/pdb |
Descriptor | Serine/threonine-protein kinase PAK 4, 5-cyano-~{N}-methyl-pyrazolo[1,5-a]pyridine-3-carboxamide (3 entities in total) |
Functional Keywords | protein kinase, pak4, atp-binding, transferase, technology |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 33580.94 |
Authors | Baker, L.M.,Murray, J.B.,Hubbard, R.E. (deposition date: 2022-07-21, release date: 2022-09-14, Last modification date: 2024-01-31) |
Primary citation | Ma, H.,Murray, J.B.,Luo, H.,Cheng, X.,Chen, Q.,Song, C.,Duan, C.,Tan, P.,Zhang, L.,Liu, J.,Morgan, B.A.,Li, J.,Wan, J.,Baker, L.M.,Finnie, W.,Guetzoyan, L.,Harris, R.,Hendrickson, N.,Matassova, N.,Simmonite, H.,Smith, J.,Hubbard, R.E.,Liu, G. PAC-FragmentDEL - photoactivated covalent capture of DNA-encoded fragments for hit discovery. Rsc Med Chem, 13:1341-1349, 2022 Cited by PubMed: 36426238DOI: 10.1039/d2md00197g PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.037 Å) |
Structure validation
Download full validation report