8ADJ

Poly(ADP-ribose) glycohydrolase (PARG) from Drosophila melanogaster in complex with PARG inhibitor PDD00017272

8ADJ の概要

• エントリーDOI: 10.2210/pdb8adj/pdb
• 分子名称: Poly(ADP-ribose) glycohydrolase, 1-[(2,5-dimethylpyrazol-3-yl)methyl]-N-(1-methylcyclopropyl)-3-[(2-methyl-1,3-thiazol-5-yl)methyl]-2,4-bis(oxidanylidene)quinazoline-6-sulfonamide, GLYCEROL, ... (6 entities in total)
• 機能のキーワード: parg, poly(adp-ribose) glycohydrolase, inhibitor, pdd00017272, hydrolase
• 由来する生物種: Drosophila melanogaster (fruit fly)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 200667.99

構造登録者

Ariza, A.,Fontana, P. (登録日: 2022-07-08, 公開日: 2023-06-14, 最終更新日: 2024-02-07)

• 主引用文献: Fontana, P.,Buch-Larsen, S.C.,Suyari, O.,Smith, R.,Suskiewicz, M.J.,Schutzenhofer, K.,Ariza, A.,Rack, J.G.M.,Nielsen, M.L.,Ahel, I.; Serine ADP-ribosylation in Drosophila provides insights into the evolution of reversible ADP-ribosylation signalling.; Nat Commun, 14:3200-3200, 2023; PubMed: 37268618; DOI: 10.1038/s41467-023-38793-y

実験手法

X-RAY DIFFRACTION (2.508 Å)