8A5X

Crystal structure of phosphatidyl inositol 4-kinase II beta in complex with MM1373

Summary for 8A5X

• Entry DOI: 10.2210/pdb8a5x/pdb
• Descriptor: Phosphatidylinositol 4-kinase type 2-beta,Endolysin, 4-azanyl-7-[3-(hydroxymethyl)phenyl]quinazoline-6-carboxamide (3 entities in total)
• Functional Keywords: lipid, kinase, pi4k2b, inhibitor, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 59662.21

Authors

Klima, M.,Boura, E. (deposition date: 2022-06-16, release date: 2022-10-05, Last modification date: 2024-01-31)

• Primary citation: Misehe, M.,Klima, M.,Matousova, M.,Chalupska, D.,Dejmek, M.,Sala, M.,Mertlikova-Kaiserova, H.,Boura, E.,Nencka, R.; Structure-based design and modular synthesis of novel PI4K class II inhibitors bearing a 4-aminoquinazoline scaffold.; Bioorg.Med.Chem.Lett., 76:129010-129010, 2022; PubMed: 36184029; DOI: 10.1016/j.bmcl.2022.129010

Experimental method

X-RAY DIFFRACTION (2.4 Å)