8A3Q

Human Plasma Kallekrein in complex with 14W

8A3Q の概要

• エントリーDOI: 10.2210/pdb8a3q/pdb
• 分子名称: Plasma kallikrein, UNKNOWN LIGAND, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (5 entities in total)
• 機能のキーワード: inhibitor, complex, serine-like protease, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29782.66

構造登録者

McEwan, P.A. (登録日: 2022-06-08, 公開日: 2022-11-02, 最終更新日: 2024-01-31)

• 主引用文献: Davie, R.L.,Edwards, H.J.,Evans, D.M.,Hodgson, S.T.,Stocks, M.J.,Smith, A.J.,Rushbrooke, L.J.,Pethen, S.J.,Roe, M.B.,Clark, D.E.,McEwan, P.A.,Hampton, S.L.; Sebetralstat (KVD900): A Potent and Selective Small Molecule Plasma Kallikrein Inhibitor Featuring a Novel P1 Group as a Potential Oral On-Demand Treatment for Hereditary Angioedema.; J.Med.Chem., 65:13629-13644, 2022; PubMed: 36251573; DOI: 10.1021/acs.jmedchem.2c00921

実験手法

X-RAY DIFFRACTION (1.801 Å)