8A2Q

Structure of the DNA-bound FANCD2-FANCI complex containing phosphomimetic FANCI

8A2Q の概要

• エントリーDOI: 10.2210/pdb8a2q/pdb
• EMDBエントリー: 15101 15102 15103
• 分子名称: FANCD2, Fanconi anemia complementation group I, DNA (29-MER), ... (4 entities in total)
• 機能のキーワード: nucleic acid protein complex, dna clamp, solenoid domains, fanconi anemia, dna repair, dna damage, dna inter strand crosslink, dna binding protein, ubiquitination, atr, pathway activation
• 由来する生物種: Gallus gallus (chicken); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 342184.91

構造登録者

Passmore, L.A.,Sijacki, T.,Alcon, P. (登録日: 2022-06-06, 公開日: 2022-09-07, 最終更新日: 2022-10-05)

• 主引用文献: Sijacki, T.,Alcon, P.,Chen, Z.A.,McLaughlin, S.H.,Shakeel, S.,Rappsilber, J.,Passmore, L.A.; The DNA-damage kinase ATR activates the FANCD2-FANCI clamp by priming it for ubiquitination.; Nat.Struct.Mol.Biol., 29:881-890, 2022; PubMed: 36050501; DOI: 10.1038/s41594-022-00820-9

実験手法

ELECTRON MICROSCOPY (3.53 Å)