8A16

Human PTPRM domains FN3-4, in spacegroup P212121

Summary for 8A16

• Entry DOI: 10.2210/pdb8a16/pdb
• Descriptor: Receptor-type tyrosine-protein phosphatase mu, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• Functional Keywords: receptor phosphatase, homophilic dimer, cell adhesion
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 59768.34

Authors

Caroe, E.,Graham, S.C.,Sharpe, H.J.,Deane, J.E. (deposition date: 2022-05-31, release date: 2023-03-15, Last modification date: 2024-02-07)

• Primary citation: Hay, I.M.,Shamin, M.,Caroe, E.R.,Mohammed, A.S.A.,Svergun, D.I.,Jeffries, C.M.,Graham, S.C.,Sharpe, H.J.,Deane, J.E.; Determinants of receptor tyrosine phosphatase homophilic adhesion: Structural comparison of PTPRK and PTPRM extracellular domains.; J.Biol.Chem., 299:102750-102750, 2023; PubMed: 36436563; DOI: 10.1016/j.jbc.2022.102750

Experimental method

X-RAY DIFFRACTION (2.89 Å)