8ZKA

Crystal structure of the Decarboxylase KDC4427 in complex with phenylpyruvic acid intermediate

This is a non-PDB format compatible entry.

Summary for 8ZKA

• Entry DOI: 10.2210/pdb8zka/pdb
• Descriptor: Indolepyruvate decarboxylase, MAGNESIUM ION, 2-[(2~{E})-3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-2-(1-oxidanyl-2-phenyl-ethylidene)-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate, ... (4 entities in total)
• Functional Keywords: decarboxylase, lyase
• Biological source: Enterobacter sp. CGMCC 5087
• Total number of polymer chains: 2
• Total formula weight: 125052.16

Authors

Dong, S.,Liu, L.,Zhang, H. (deposition date: 2024-05-15, release date: 2025-05-21, Last modification date: 2026-05-20)

• Primary citation: Dong, S.,Liu, L.,Yang, Y.,Liao, W.,Zhang, X.,Ling, C.,Han, Y.,Wang, L.,Zhang, H.; Mechanistic Insights into the Substrate Promiscuity of alpha-Ketoacid Decarboxylases for Enhanced Higher-Alcohol Biosynthesis; Acs Sustain Chem Eng, 2026; DOI: 10.1021/acssuschemeng.5c13943

Experimental method

X-RAY DIFFRACTION (1.95 Å)