8WY3
Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor 21
Summary for 8WY3
Entry DOI | 10.2210/pdb8wy3/pdb |
Descriptor | Bromodomain-containing protein 4, ~{N}-cyclopropyl-2-[[5-[2-(4-fluoranyl-2,6-dimethyl-phenoxy)-5-(2-oxidanylpropan-2-yl)phenyl]-1-methyl-2-oxidanylidene-pyridin-4-yl]amino]ethanamide (3 entities in total) |
Functional Keywords | brd4(1), bromodomain, protein binding |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 3 |
Total formula weight | 51782.69 |
Authors | |
Primary citation | Jiang, W.,Hou, Q.,Xu, H.,Yang, K.,Wang, X.,Zhang, K.,Zeng, Y.,Li, W.,Wang, B.,Luo, G.,Zhao, X.,Shen, H.,Xu, Y.,Wu, X. Discovery of Novel Phenoxyaryl Pyridones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with High Selectivity for the Second Bromodomain (BD2) to Potentially Treat Acute Myeloid Leukemia. J.Med.Chem., 67:1513-1532, 2024 Cited by PubMed: 38175809DOI: 10.1021/acs.jmedchem.3c02104 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.78 Å) |
Structure validation
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