8WTX
Cryo-EM structure of noradrenaline transporter in complex with bupropion
Summary for 8WTX
Entry DOI | 10.2210/pdb8wtx/pdb |
EMDB information | 37845 |
Descriptor | Sodium-dependent noradrenaline transporter, (2~{R})-2-(~{tert}-butylamino)-1-(3-chlorophenyl)propan-1-one (2 entities in total) |
Functional Keywords | noradrenaline transporter, inhibition, bupropion, structural protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 64040.85 |
Authors | |
Primary citation | Hu, T.,Yu, Z.,Zhao, J.,Meng, Y.,Salomon, K.,Bai, Q.,Wei, Y.,Zhang, J.,Xu, S.,Dai, Q.,Yu, R.,Yang, B.,Loland, C.J.,Zhao, Y. Transport and inhibition mechanisms of the human noradrenaline transporter. Nature, 632:930-937, 2024 Cited by PubMed: 39085602DOI: 10.1038/s41586-024-07638-z PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.9 Å) |
Structure validation
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