8WQ7
Crystal structure of d(CGTATACG)2 with a four-carbon linker containing diacridine compound
Summary for 8WQ7
Entry DOI | 10.2210/pdb8wq7/pdb |
Descriptor | DNA (5'-D(P*CP*GP*TP*AP*TP*AP*CP*G)-3'), MANGANESE (II) ION, N,N'-di(acridin-9-yl)butane-1,4-diamine, ... (4 entities in total) |
Functional Keywords | drug-dna complex, bis-intercalator, acridine, dna |
Biological source | synthetic construct |
Total number of polymer chains | 2 |
Total formula weight | 5405.66 |
Authors | Huang, S.C.,Satange, R.B.,Hou, M.H. (deposition date: 2023-10-11, release date: 2024-08-07, Last modification date: 2024-09-11) |
Primary citation | Huang, S.C.,Chen, C.W.,Satange, R.,Hsieh, C.C.,Chang, C.C.,Wang, S.C.,Peng, C.L.,Chen, T.L.,Chiang, M.H.,Horng, Y.C.,Hou, M.H. Targeting DNA junction sites by bis-intercalators induces topological changes with potent antitumor effects. Nucleic Acids Res., 52:9303-9316, 2024 Cited by PubMed: 39036959DOI: 10.1093/nar/gkae643 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.58 Å) |
Structure validation
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