8WCI

Cryo-EM structure of the inhibitor-bound Vo complex from Enterococcus hirae

Summary for 8WCI

• Entry DOI: 10.2210/pdb8wci/pdb
• EMDB information: 37440
• Descriptor: V-type sodium ATPase subunit K, V-type sodium ATPase subunit I, CARDIOLIPIN, ... (6 entities in total)
• Functional Keywords: v-atpase, na+-transporting, membrane protein, atp hydrolyses, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Enterococcus hirae ATCC 9790; More
• Total number of polymer chains: 11
• Total formula weight: 244733.13

Authors

Suzuki, K.,Mikuriya, S.,Adachi, N.,Kawasaki, M.,Senda, T.,Moriya, T.,Murata, T. (deposition date: 2023-09-12, release date: 2024-10-09)

• Primary citation: Suzuki, K.,Goto, Y.,Otomo, A.,Shimizu, K.,Abe, S.,Moriyama, K.,Yasuda, S.,Hashimoto, Y.,Kurushima, J.,Mikuriya, S.,Imai, F.L.,Adachi, N.,Kawasaki, M.,Sato, Y.,Ogasawara, S.,Iwata, I.,Senda, T.,Ikeguchi, M.,Tomita, H.,Iino, R.,Moriya, T.,Murata, T.; Novel Inhibitor of Na+-Transporting V-ATPase Suppresses VRE Colonization in Mice and Reveals the High-Resolution Structure of the Na+ Transport Pathway; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.2 Å)