8W9A
CryoEM structure of human PI3K-alpha (P85/P110-H1047R) with QR-7909 binding at an allosteric site
Summary for 8W9A
Entry DOI | 10.2210/pdb8w9a/pdb |
EMDB information | 37362 |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, 6-chloranyl-3-[[(1R)-1-[2-(1,3-dihydropyrrolo[3,4-c]pyridin-2-yl)-3,6-dimethyl-4-oxidanylidene-quinazolin-8-yl]ethyl]amino]pyridine-2-carboxylic acid, ... (4 entities in total) |
Functional Keywords | pi3k-alpha, lipid kinase, allosteric inhibition, oncoprotein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 208431.97 |
Authors | |
Primary citation | Huang, X.,Wang, K.,Han, J.,Chen, X.,Wang, Z.,Wu, T.,Yu, B.,Zhao, F.,Wang, X.,Li, H.,Xie, Z.,Zhu, X.,Zhong, W.,Ren, X. Cryo-EM structures reveal two allosteric inhibition modes of PI3K alpha H1047R involving a re-shaping of the activation loop. Structure, 32:907-917.e7, 2024 Cited by PubMed: 38582077DOI: 10.1016/j.str.2024.03.007 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.7 Å) |
Structure validation
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