8VF6

Crystal structure of Serine/threonine-protein kinase 33 (STK33) Kinase Domain in complex with inhibitor CDD-2211

This is a non-PDB format compatible entry.

Summary for 8VF6

• Entry DOI: 10.2210/pdb8vf6/pdb
• Descriptor: Serine/threonine-protein kinase 33, {3-[([1,1'-biphenyl]-2-yl)ethynyl]-1H-indazol-5-yl}[(3R)-3-(dimethylamino)pyrrolidin-1-yl]methanone (3 entities in total)
• Functional Keywords: kinase, stk33, cytosolic protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 65938.19

Authors

Ta, H.M.,Kim, C.,Ku, K.A.,Matzuk, M.M. (deposition date: 2023-12-21, release date: 2024-06-05)

• Primary citation: Ku, A.F.,Sharma, K.L.,Ta, H.M.,Sutton, C.M.,Bohren, K.M.,Wang, Y.,Chamakuri, S.,Chen, R.,Hakenjos, J.M.,Jimmidi, R.,Kent, K.,Li, F.,Li, J.Y.,Ma, L.,Madasu, C.,Palaniappan, M.,Palmer, S.S.,Qin, X.,Robers, M.B.,Sankaran, B.,Tan, Z.,Vasquez, Y.M.,Wang, J.,Wilkinson, J.,Yu, Z.,Ye, Q.,Young, D.W.,Teng, M.,Kim, C.,Matzuk, M.M.; Reversible male contraception by targeted inhibition of serine/threonine kinase 33.; Science, 384:885-890, 2024; PubMed: 38781365; DOI: 10.1126/science.adl2688

Experimental method

X-RAY DIFFRACTION (2.7 Å)