8V15

Human SIRT3 bound to p53-AMC peptide, Carba-NAD, and Honokiol

Summary for 8V15

Entry DOI	10.2210/pdb8v15/pdb
Descriptor	NAD-dependent protein deacetylase sirtuin-3, mitochondrial, GLN-PRO-LYS-FDL, ZINC ION, ... (6 entities in total)
Functional Keywords	activator, complex, deacylase, hydrolase
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	65801.87
Authors	Chakrabarti, R.,Ghosh, A.,Guan, X.,Upadhyay, A.,Dumpati, R.K.,Munshi, S.,Roy, S.,Chall, S.,Rahnamoun, A.,Reverdy, C.,Errasti, G.,Delacroix, T. (deposition date: 2023-11-19, release date: 2023-12-06)
Primary citation	Chakrabarti, R.,Ghosh, A.,Guan, X.,Upadhyay, A.,Dumpati, R.K.,Munshi, S.,Roy, S.,Chall, S.,Rahnamoun, A.,Reverdy, C.,Errasti, G.,Delacroix, T. Computationally Driven Discovery and Characterization of SIRT3 Activating Compounds that Fully Recover Catalytic Activity under NAD+ Depletion biorxiv, 2023 Cited by DOI: 10.1101/2023.11.09.566481 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation