8UD8
Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution
This is a non-PDB format compatible entry.
Summary for 8UD8
Entry DOI | 10.2210/pdb8ud8/pdb |
Descriptor | 23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (61 entities in total) |
Functional Keywords | cresomycin, lincosamides, structure-based drug design, antibiotic, resistance, cfr, erm, methylation, a2058, a2503, 23s rrna, 70s ribosome, inhibition of translation, peptidyl transferase center, nascent peptide exit tunnel, ribosome, ribosome-rna complex, ribosome/rna |
Biological source | Escherichia coli More |
Total number of polymer chains | 112 |
Total formula weight | 4570438.93 |
Authors | Aleksandrova, E.V.,Syroegin, E.A.,Wu, K.J.Y.,Tresco, B.I.C.,Ramkissoon, A.,See, D.N.Y.,Liow, P.,Dittemore, G.A.,Yu, M.,Testolin, G.,Mitcheltree, M.J.,Liu, R.Y.,Svetlov, M.S.,Myers, A.G.,Polikanov, Y.S. (deposition date: 2023-09-28, release date: 2024-02-21, Last modification date: 2024-02-28) |
Primary citation | Wu, K.J.Y.,Tresco, B.I.C.,Ramkissoon, A.,Aleksandrova, E.V.,Syroegin, E.A.,See, D.N.Y.,Liow, P.,Dittemore, G.A.,Yu, M.,Testolin, G.,Mitcheltree, M.J.,Liu, R.Y.,Svetlov, M.S.,Polikanov, Y.S.,Myers, A.G. An antibiotic preorganized for ribosomal binding overcomes antimicrobial resistance. Science, 383:721-726, 2024 Cited by PubMed: 38359125DOI: 10.1126/science.adk8013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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