8U4K

Structure of the HER2/HER4/BTC Heterodimer Extracellular Domain

Summary for 8U4K

• Entry DOI: 10.2210/pdb8u4k/pdb
• EMDB information: 41883 41884 41885 41886
• Descriptor: Isoform JM-A CYT-1 of Receptor tyrosine-protein kinase erbB-4, Receptor tyrosine-protein kinase erbB-2, Betacellulin, ... (9 entities in total)
• Functional Keywords: receptor tyrosine kinase, membrane protein, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 147281.49

Authors

Trenker, R.,Diwanji, D.,Bingham, T.,Verba, K.A.,Jura, N. (deposition date: 2023-09-10, release date: 2024-03-13, Last modification date: 2024-09-25)

• Primary citation: Trenker, R.,Diwanji, D.,Bingham, T.,Verba, K.A.,Jura, N.; Structural dynamics of the active HER4 and HER2/HER4 complexes is finely tuned by different growth factors and glycosylation.; Elife, 12:-, 2024; PubMed: 38498590; DOI: 10.7554/eLife.92873

Experimental method

ELECTRON MICROSCOPY (4.27 Å)