8TCZ
Structure of PYCR1 complexed with 2-(pyridin-2-yl)cyclopropane-1-carboxylic acid
Summary for 8TCZ
Entry DOI | 10.2210/pdb8tcz/pdb |
Descriptor | Pyrroline-5-carboxylate reductase 1, mitochondrial, SULFATE ION, (1S,2S)-2-(pyridin-2-yl)cyclopropane-1-carboxylic acid, ... (4 entities in total) |
Functional Keywords | amino-acid biosynthesis, oxidoreductase, proline biosynthesis |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 5 |
Total formula weight | 168402.42 |
Authors | Tanner, J.J.,Meeks, K.R. (deposition date: 2023-07-02, release date: 2024-03-06, Last modification date: 2024-03-20) |
Primary citation | Meeks, K.R.,Ji, J.,Protopopov, M.V.,Tarkhanova, O.O.,Moroz, Y.S.,Tanner, J.J. Novel Fragment Inhibitors of PYCR1 from Docking-Guided X-ray Crystallography. J.Chem.Inf.Model., 64:1704-1718, 2024 Cited by PubMed: 38411104DOI: 10.1021/acs.jcim.3c01879 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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