8T7D
Crystal structure of wild type IDH1 bound to compound 1
Summary for 8T7D
Entry DOI | 10.2210/pdb8t7d/pdb |
Descriptor | Isocitrate dehydrogenase [NADP] cytoplasmic, N-(4-tert-butylphenyl)-7,8-dimethyl-5,11-dihydro-6H-pyrido[2,3-b][1,5]benzodiazepine-6-carboxamide (2 entities in total) |
Functional Keywords | oxidoreductase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 193872.67 |
Authors | Lu, J.,Abeywickrema, P.,Heo, M.R.,Parthasarathy, G.,McCoy, M.,Soisson, S.M. (deposition date: 2023-06-20, release date: 2024-08-28) |
Primary citation | McCoy, M.A.,Lu, J.,Miller, R.,Soisson, S.M.,Lam, M.H.,Fischer, C. Mechanistic and Biostructural Studies of Mutant IDH1 To Be Published, |
Experimental method | X-RAY DIFFRACTION (3.444 Å) |
Structure validation
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