8SVS
Crystal structure of pregnane X receptor ligand binding domain in complex with SJPYT-328
Summary for 8SVS
Entry DOI | 10.2210/pdb8svs/pdb |
Descriptor | Nuclear receptor subfamily 1 group I member 2, Nuclear receptor coactivator 1 fusion protein,Nuclear receptor coactivator 1, (1P)-N-(5-tert-butyl-2-{[(3S)-hexan-3-yl]oxy}phenyl)-1-(2,4-dimethoxy-5-methylphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide (3 entities in total) |
Functional Keywords | pregnane x receptor (pxr), promiscuous ligand-activated protein, nuclear receptor subfamily 1, transcriptional regulator, drug metabolism, transcription |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 80808.57 |
Authors | Garcia-Maldonado, E.,Huber, A.D.,Nithianantham, S.,Miller, D.J.,Chen, T. (deposition date: 2023-05-17, release date: 2024-05-15, Last modification date: 2024-06-05) |
Primary citation | Garcia-Maldonado, E.,Huber, A.D.,Chai, S.C.,Nithianantham, S.,Li, Y.,Wu, J.,Poudel, S.,Miller, D.J.,Seetharaman, J.,Chen, T. Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR. Nat Commun, 15:4054-4054, 2024 Cited by PubMed: 38744881DOI: 10.1038/s41467-024-48472-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.68 Å) |
Structure validation
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