8SV9
Crystal structure of ULK1 kinase domain with inhibitor MR-2088
Summary for 8SV9
Entry DOI | 10.2210/pdb8sv9/pdb |
Descriptor | Serine/threonine-protein kinase ULK1, (4P)-4-[(2P)-2-(1,2,5,6-tetrahydropyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N-(2,2,2-trifluoroethyl)thiophene-2-carboxamide, SULFATE ION, ... (5 entities in total) |
Functional Keywords | autophagy, inhibitor, complex, kinase, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 65735.31 |
Authors | |
Primary citation | Morozova, A.,Chan, S.C.,Bayle, S.,Sun, L.,Grassie, D.,Iermolaieva, A.,Kalaga, M.N.,Frydman, S.,Sansil, S.,Schonbrunn, E.,Duckett, D.,Monastyrskyi, A. Development of potent and selective ULK1/2 inhibitors based on 7-azaindole scaffold with favorable in vivo properties. Eur.J.Med.Chem., 266:116101-116101, 2024 Cited by PubMed: 38232465DOI: 10.1016/j.ejmech.2023.116101 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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