8SRG

Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium, Adenosine monophosphate, and Ribose-5-phosphate

Summary for 8SRG

Entry DOI	10.2210/pdb8srg/pdb
EMDB information	40730 40867 40883
Descriptor	TRPM2 chanzyme, 5-O-phosphono-beta-D-ribofuranose, ADENOSINE MONOPHOSPHATE, ... (5 entities in total)
Functional Keywords	trpm2 chanzyme, channel-enzyme, membrane protein
Biological source	Salpingoeca rosetta
Total number of polymer chains	4
Total formula weight	680347.99
Authors	Huang, Y.,Kumar, S.,Lu, W.,Du, J. (deposition date: 2023-05-05, release date: 2024-05-15, Last modification date: 2024-10-16)
Primary citation	Huang, Y.,Kumar, S.,Lee, J.,Lu, W.,Du, J. Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution. Nat.Struct.Mol.Biol., 2024 Cited by PubMed: 38773335 DOI: 10.1038/s41594-024-01316-4 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.03 Å)

Structure validation