8SIR

Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with broadly neutralizing antibody CC25.54 Fab

Summary for 8SIR

• Entry DOI: 10.2210/pdb8sir/pdb
• Descriptor: Spike protein S1, CC25.54 Fab heavy chain, CC25.54 Fab light chain, ... (4 entities in total)
• Functional Keywords: bnab, sars-cov-2, broadly neutralizing antibody, spike, rbd, immune system
• Biological source: Severe acute respiratory syndrome coronavirus 2; More
• Total number of polymer chains: 3
• Total formula weight: 72703.98

Authors

Liu, H.,Wilson, I.A. (deposition date: 2023-04-16, release date: 2024-03-13, Last modification date: 2024-11-13)

• Primary citation: Song, G.,Yuan, M.,Liu, H.,Capozzola, T.,Lin, R.,Torres, J.,He, W.,Musharrafieh, R.,Dueker, K.,Zhou, P.,Callaghan, S.,Mishra, N.,Yong, P.,Anzanello, F.,Avillion, G.,Vo, A.,Li, X.,Makhdoomi, M.,Feng, Z.,Zhu, X.,Peng, L.,Nemazee, D.,Safonova, Y.,Briney, B.,Ward, A.,Burton, D.,Wilson, I.,Andrabi, R.; Broadly neutralizing antibodies targeting a conserved silent face of spike RBD resist extreme SARS-CoV-2 antigenic drift; Biorxiv, 2023; DOI: 10.1101/2023.04.26.538488

Experimental method

X-RAY DIFFRACTION (3.3 Å)