8R7I
X-ray structure of blue laccase BP76 from the termite Neocapritermes taracua
This is a non-PDB format compatible entry.
Summary for 8R7I
| Entry DOI | 10.2210/pdb8r7i/pdb |
| Descriptor | Laccase BP76, COPPER (II) ION, CHLORIDE ION, ... (13 entities in total) |
| Functional Keywords | insect, defence, protein stabilisation, glycosylation, allysine, oxidoreductase |
| Biological source | Neocapritermes taracua |
| Total number of polymer chains | 1 |
| Total formula weight | 75460.01 |
| Authors | Skerlova, J.,Brynda, J.,Rezacova, P. (deposition date: 2023-11-24, release date: 2024-08-28, Last modification date: 2024-10-16) |
| Primary citation | Skerlova, J.,Brynda, J.,Sobotnik, J.,Zakopcanik, M.,Novak, P.,Bourguignon, T.,Sillam-Dusses, D.,Rezacova, P. Crystal structure of blue laccase BP76, a unique termite suicidal defense weapon. Structure, 32:1581-, 2024 Cited by PubMed Abstract: Aging workers of the termite Neocapritermes taracua can defend their colony by sacrificing themselves by body rupture, mixing the externally stored blue laccase BP76 with hydroquinones to produce a sticky liquid rich in toxic benzoquinones. Here, we describe the crystal structure of BP76 isolated from N. taracua in its native form. The structure reveals several stabilization strategies, including compact folding, glycosylation, and flexible loops with disulfide bridges and tight dimer interface. The remarkable stability of BP76 maintains its catalytic activity in solid state during the lifespan of N. taracua workers, providing old workers with an efficient defensive weapon to protect their colony. PubMed: 39151418DOI: 10.1016/j.str.2024.07.015 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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