8QDY
Crystal structure of human MAT2a bound to S-Adenosylmethionine and Compound 8
Summary for 8QDY
Entry DOI | 10.2210/pdb8qdy/pdb |
Descriptor | S-adenosylmethionine synthase isoform type-2, 3-cyclopropyl-4-(4-methoxyphenyl)-1~{H}-pyrazolo[4,3-c]pyridine, S-ADENOSYLMETHIONINE, ... (4 entities in total) |
Functional Keywords | s-adenosylmethionine biosynthesis, allosteric inhibitor, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 44599.57 |
Authors | Schimpl, M. (deposition date: 2023-08-30, release date: 2024-03-20, Last modification date: 2024-04-10) |
Primary citation | Atkinson, S.J.,Bagal, S.K.,Argyrou, A.,Askin, S.,Cheung, T.,Chiarparin, E.,Coen, M.,Collie, I.T.,Dale, I.L.,De Fusco, C.,Dillman, K.,Evans, L.,Feron, L.J.,Foster, A.J.,Grondine, M.,Kantae, V.,Lamont, G.M.,Lamont, S.,Lynch, J.T.,Nilsson Lill, S.,Robb, G.R.,Saeh, J.,Schimpl, M.,Scott, J.S.,Smith, J.,Srinivasan, B.,Tentarelli, S.,Vazquez-Chantada, M.,Wagner, D.,Walsh, J.J.,Watson, D.,Williamson, B. Development of a Series of Pyrrolopyridone MAT2A Inhibitors. J.Med.Chem., 67:4541-4559, 2024 Cited by PubMed: 38466661DOI: 10.1021/acs.jmedchem.3c01860 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.19 Å) |
Structure validation
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