8Q3U
Crystal structure of a fentanyl derivative in complex with human CA VII
Summary for 8Q3U
Entry DOI | 10.2210/pdb8q3u/pdb |
Descriptor | Carbonic anhydrase 7, ZINC ION, ~{N}-phenyl-~{N}-[1-[2-(4-sulfamoylphenyl)ethyl]piperidin-4-yl]propanamide, ... (5 entities in total) |
Functional Keywords | carbonic anhydrase, fentanyl derivative, metalloenzyme, complex, lyase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 31590.84 |
Authors | |
Primary citation | Angeli, A.,Micheli, L.,Turnaturi, R.,Pasquinucci, L.,Parenti, C.,Alterio, V.,Di Fiore, A.,De Simone, G.,Monti, S.M.,Carta, F.,Di Cesare Mannelli, L.,Ghelardini, C.,Supuran, C.T. Discovery of a novel series of potent carbonic anhydrase inhibitors with selective affinity for mu Opioid receptor for Safer and long-lasting analgesia. Eur.J.Med.Chem., 260:115783-115783, 2023 Cited by PubMed: 37678143DOI: 10.1016/j.ejmech.2023.115783 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.1 Å) |
Structure validation
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