8PQG
c-KIT T670I mutated kinase domain in complex with avapritinib
Summary for 8PQG
Entry DOI | 10.2210/pdb8pqg/pdb |
Descriptor | Mast/stem cell growth factor receptor Kit, Avapritinib (3 entities in total) |
Functional Keywords | c-kit protein kinase, avapritinib, inhibitor, tyrosine kinase, transmembrane receptor, stem cell factor, scf, stem cell factor receptor, gist, gastrointestinal stromal tumors, gatekeeper mutant, gatekeeper mutation, p10721, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 75410.08 |
Authors | Teuber, A.,Mueller, M.P.,Rauh, D. (deposition date: 2023-07-11, release date: 2023-12-27, Last modification date: 2024-08-07) |
Primary citation | Teuber, A.,Schulz, T.,Fletcher, B.S.,Gontla, R.,Muhlenberg, T.,Zischinsky, M.L.,Niggenaber, J.,Weisner, J.,Kleinbolting, S.B.,Lategahn, J.,Sievers, S.,Muller, M.P.,Bauer, S.,Rauh, D. Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA. Nat Commun, 15:63-63, 2024 Cited by PubMed: 38167404DOI: 10.1038/s41467-023-44376-8 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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