8P99

SARS-CoV-2 S-protein:D614G mutant in 1-up conformation

Summary for 8P99

Entry DOI	10.2210/pdb8p99/pdb
EMDB information	17576
Descriptor	Spike protein S1,Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
Functional Keywords	spike, sars cov-2, inhibitor, viral protein
Biological source	Severe acute respiratory syndrome coronavirus 2 More
Total number of polymer chains	3
Total formula weight	432265.33
Authors	Adhav, A.,Forcada-Nadal, A.,Marco-Marin, C.,Lopez-Redondo, M.L.,Llacer, J.L. (deposition date: 2023-06-05, release date: 2023-09-27)
Primary citation	Gargantilla, M.,Frances, C.,Adhav, A.,Forcada-Nadal, A.,Martinez-Gualda, B.,Marti-Mari, O.,Lopez-Redondo, M.L.,Melero, R.,Marco-Marin, C.,Gougeard, N.,Espinosa, C.,Rubio-Del-Campo, A.,Ruiz-Partida, R.,Hernandez-Sierra, M.D.P.,Villamayor-Belinchon, L.,Bravo, J.,Llacer, J.L.,Marina, A.,Rubio, V.,San-Felix, A.,Geller, R.,Perez-Perez, M.J. C-2 Thiophenyl Tryptophan Trimers Inhibit Cellular Entry of SARS-CoV-2 through Interaction with the Viral Spike (S) Protein. J.Med.Chem., 66:10432-10457, 2023 Cited by PubMed: 37471688 DOI: 10.1021/acs.jmedchem.3c00576 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.4 Å)

Structure validation