8OWA
SR Ca(2+)-ATPase in the E2 state complexed with the photoswitch-thapsigargin derivative AzTG-4
Summary for 8OWA
Entry DOI | 10.2210/pdb8owa/pdb |
Descriptor | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, ACETYL GROUP, [(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-acetyloxy-3,6,9-trimethyl-8-[(Z)-2-methylbut-2-enoyl]oxy-3,3a-bis(oxidanyl)-2-oxidanylidene-4-[4-[4-[(E)-phenyldiazenyl]phenyl]butanoyloxy]-4,5,6a,7,8,9b-hexahydroazuleno[4,5-b]furan-7-yl] octanoate, ... (4 entities in total) |
Functional Keywords | serca inhibitors, photoswitch, azobenzene, thapsigargin, hydrolase |
Biological source | Oryctolagus cuniculus (rabbit) |
Total number of polymer chains | 1 |
Total formula weight | 110201.25 |
Authors | Hjorth-Jensen, S.J.,Konrad, D.B.,Quistgaard, E.M.H.,Hansen, L.C.,Novak, A.,Chu, H.,Jurasek, M.,Zimmermann, T.,Andersen, J.L.,Baran, P.S.,Nissen, P.,Trauner, D. (deposition date: 2023-04-27, release date: 2023-06-21) |
Primary citation | Hjorth-Jensen, S.J.,Konrad, D.B.,Quistgaard, E.M.H.,Hansen, L.C.,Novak, A.,Chu, H.,Jurasek, M.,Zimmermann, T.,Andersen, J.L.,Baran, P.S.,Nissen, P.,Trauner, D. Photoswitchable inhibitors of the sarco(endo)plasmic calcium pump To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.85 Å) |
Structure validation
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